How Do Antirheumatics work?

The conventional method of medical treatment has earned a negative connotation as it relates to the instant referral of the chemical drugs. The particular behavior of immediate prescribing after the diagnosis has led to the evolution of human body and have made their bodies immune to the drugs. However, we are going to break down the information on antirheumatics drugs and their working principle.

 

 What Are Antirheumatic Drugs?

Much like all the traditional drugs, antirheumatic drugs are the group of medicines which are prescribed to offer immediate medical aid for rheumatoid arthritis (RA). It is also called as Disease-modifying antirheumatic drugs (DMARDs).

What Are DMARDs Given For?

Disease-modifying antirheumatic drugs are given for rheumatic disorder, a disorder which is a blanket term for conditions causing chronic, often sporadic pain affecting the connective tissues and joints. The symptoms may vary from pain to stiffness. The disease may also result in lowering the red blood cell count.

1. RA is considered as an autoimmune disease where the immune system attacks its own tissues. The ability to make antibodies in the form of small proteins not only attack the bacteria and germs but also kills its vital tissues.
2. In victims suffering from RA, antibodies are developed around the joints and against the own connective tissues (around the synovial membrane). This results in inflammatory effect in and around the joints.
3. Over time this can also cause inflammation around important body parts like heart and lung, deplete the cartilage, and parts of the bone juxtapositioned to the joint.
4. Small joints like those of fingers, thumbs, feet, wrists, etc are most prone to the antibodies attack.

Which DMARDs Are Available In The Market?

There is a good amount of DMARDs available in the market for treating RA. They are cyclosporine, azathioprine, penicillamine, leflunomide, mycophenolate mofetil (MMF), methotrexate, hydroxychloroquine, sulfasalazine and sodium aurothiomalate. DMARDs Can Also be Used to treat chronic ailment like chronic inflammatory skin or bowel disease.

What Is The Working Principle Of Disease-Modifying Antirheumatic Drugs?

The medical research is running short of explanation on how DMARDs work. But it is believed that it just like inflammation is developed in the joints, they block certain chemicals which are responsible for causing the inflammation process.

Which Is The Most Prescribed DMARD drug?

While there are several DMARDs available in the market, Methotrexate is majorly prescribed for initial stages of RA. However, the doctor may prescribe something else depending on the intensity and other issues about your illness.

What Are The Side Effects Of DMARDs?

Since they are referred for a long time, they can have adverse side effects on the RA respondent. Some of the serious side effects vary from damaging the liver to blood-making cells. It is advised to tolerate them at low doses. With careful management of the dose, an individual can take it for a long time without damaging the health. The other possible side attacks include rash, nausea, abdominal discomfort, vomiting, headache,  fever, and drowsiness. Their long usage compels you to have regular blood tests, just to keep in check whether they have any side-effects or not.

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